University of Alabama at Birmingham · Microbiology & ImmunologyThe Viral Assembly Lab
Terje Dokland · Birmingham, Alabama
Research Focus
Dr. Terje Dokland's lab at the University of Alabama at Birmingham studies the structure and assembly mechanisms of the HIV-1 virus. Specifically, the lab is focused on how the virus's proteins are structured and interact during its lifecycle, which is critical for developing new therapies against HIV. The aim is to understand how the HIV virus assembles and matures, which could lead to innovative antiviral strategies.
HIV-1virus assemblyprotein structureenvelope proteinantiviral therapy
Research Aims
3AIM 01Determine the structural basis for MA lattice formation during assembly of the immature particle.
AIM 02Identify factors critical for MA lattice formation and Env incorporation.
AIM 03Elucidate the structure of the MA-gp41CT membrane complex using single-particle cryo-EM.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)structural biology techniquesprotein purificationmolecular modelinglipid membrane biochemistry
Output against the department
Publications116bottom 44% of dept.273rd of 486
this lab
most publishedleast published
Citations6.1kbottom 45% of dept.266th of 486
this lab
most citedleast cited
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