University of Michigan-Ann Arbor · PhysiologyMacdougald Adipose Lab
Ormond A Macdougald · Ann Arbor, Michigan
Research Focus
Dr. Ormond A. Macdougald's lab at the University of Michigan focuses on understanding the mechanisms behind lipodystrophy, a condition characterized by the loss of fat tissue. They study how mutations in the LMNA gene affect fat cells and related metabolic health in both mice and humans. The research aims to uncover the biological processes that lead to fat loss, particularly during puberty, and could potentially reveal new strategies for treating related metabolic disorders.
lipodystrophyadipose tissueLMNA genemetabolic healthadipocyte lossmouse modelshuman patientsgene expressioncellular morphologybiological mechanisms
Research Aims
5AIM 01Investigate the role of LMNA mutations in the loss of adipose tissue.
AIM 02Characterize the cellular and molecular mechanisms leading to adipocyte loss.
AIM 03Explore the effects of LMNA variants on adipocyte structure and function in humans.
AIM 04Analyze metabolic changes in mouse models of lipodystrophy over time.
AIM 05Evaluate the relationship between puberty and changes in adipose tissue using animal models.
Skills the Lab Values
PCRmouse modelscell culturegene expression analysishistological analysisproteomicsinducible genetic manipulationflow cytometrybiostatisticsmolecular assays
Output against the department
Publications243top 23% of dept.66th of 286
this lab
most publishedleast published
Citations32ktop 7% of dept.19th of 286
this lab
most citedleast cited
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