Johns Hopkins University · ChemistryNucleic Acid Damage Research Unit
Marc M Greenberg · Baltimore, Maryland
Research Focus
Dr. Marc M. Greenberg's lab at Johns Hopkins University focuses on the chemistry of nucleic acids, particularly how they get damaged and the biological consequences of that damage. The lab combines techniques from organic chemistry, biochemistry, and molecular biology to explore the mysteries surrounding DNA damage and devise new chemical tools to investigate cellular processes. This research could provide insights into diseases like cancer and lead to the development of new treatment strategies.
DNA damagenucleic acidsbiochemical pathwaysphotodynamic therapyPAR synthesis
Research Aims
5AIM 01Investigate how DNA damage affects cellular biology and biochemistry.
AIM 02Explore novel pathways of DNA damage and their consequences.
AIM 03Develop chemical tools to study and manipulate nucleic acids in cells.
AIM 04Synthesize modified nucleotides that enhance cellular sensitivity to DNA damage.
AIM 05Create methods for synthesizing defined-length poly(ADP-ribose) for research purposes.
Skills the Lab Values
organic chemistrymolecular biology techniquescell culturesynthesis of nucleotidesprotein cross-linking studies
Output against the department
Publications324top 35% of dept.75th of 216
this lab
most publishedleast published
Citations8.5kbottom 48% of dept.113th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.