EUEmory University · Microbiology & Immunology
Boss Immunology Lab
Jeremy M. Boss · Atlanta, Georgia
Research Focus
Dr. Jeremy M. Boss's lab focuses on understanding how B cells, which are crucial for the immune response, decide between becoming antibody-secreting cells or memory B cells. By examining the transcriptional and epigenetic mechanisms involved in this decision-making process, the lab aims to uncover the pathways that inform these fates. This research is important for developing effective vaccines and immune therapies, especially in the context of emerging infectious diseases like COVID-19.
B cell differentiationhumoral immunityepigenetic regulationmemory B cellsantibody productionimmune responsevaccinesimmunotherapy
Research Aims
4AIM 01Investigate the transcription factors that influence B cell fate decisions during early differentiation.
AIM 02Determine the impact of specific epigenetic modifiers on B cell differentiation and antibody formation.
AIM 03Evaluate how memory B cells rapidly respond to antigen rechallenge and their differentiation pathways.
AIM 04Identify unique chromatin accessibility profiles in memory B cells that allow for quicker antigen responses.
Skills the Lab Values
epigenomic assaystranscriptomic assaysin vivo mouse modelsconditional knockout techniquesreporter gene analysiscell cultureantibody assaysflow cytometryPCR
Output against the department
Publications296top 17% of dept.83rd of 486
this lab
most publishedleast published
Citations19ktop 20% of dept.98th of 486
this lab
most citedleast cited
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