University of Pennsylvania · Mathematics & StatisticsThe Harmonic Interactions Lab
Charles Edward Leonard · Philadelphia, Pennsylvania
Research Focus
Dr. Charles Edward Leonard's research lab focuses on understanding how psychoactive drugs can interact harmfully with one another, particularly among older adults who often take multiple medications. By investigating these interactions, the lab aims to uncover serious risks such as venous thromboembolism and bleeding, which can lead to hospitalizations or death. The research is crucial for improving medication safety and public health outcomes in individuals with mental health disorders.
psychoactive drugsdrug interactionsvenous thromboembolismbleedingmental health disorderspolypharmacyelderly healthreal-world evidencepharmacoepidemiology
Research Aims
3AIM 01Generate signals of harmful drug interactions from healthcare data.
AIM 02Prioritize drug interaction signals using expert panel focus groups.
AIM 03Test prioritized signals in independent populations through cohort studies.
Skills the Lab Values
longitudinal data analysiscohort study designmachine learningfocus group facilitationpharmacokineticsclinical endpoint evaluationpublic health researchdata miningrisk assessment
Output against the department
Publications50bottom 5% of dept.125th of 131
this lab
most publishedleast published
Citations839bottom 5% of dept.125th of 131
this lab
most citedleast cited
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