University of North Texas Health Science Center · PharmacologyCenter for Metabolic Liver Research
Xiaoli Sun · Fort Worth, Texas
Research Focus
Dr. Xiaoli Sun's lab focuses on understanding the complex relationship between metabolic dysfunction and liver diseases, specifically metabolic dysfunction-associated steatohepatitis (MASH) and its progression to liver cancer. The research investigates how oxidized phospholipids (OxPLs) contribute to oxidative stress and impact liver health. By exploring the mechanisms of OxPLs and their role in liver injury, the lab aims to uncover new potential therapeutic strategies for these serious health conditions.
metabolic dysfunctionsteatohepatitisoxidative stressoxidized phospholipidsliver cancerSOD2MASHliver fibrosisreactive oxygen species
Research Aims
3AIM 01Unravel the molecular mechanism by which OxPLs induce oxidative stress.
AIM 02Elaborate the role of the OxPLs-SOD2 axis in MASH pathogenesis.
AIM 03Investigate whether and how OxPLs promote the transition from MASH to liver cancer.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysoxidative stress measurementmolecular cloningprotein analysisWestern blottingimmunofluorescenceRNA extractionreal-time PCR
Output against the department
Publications358top 19% of dept.87th of 462
this lab
most publishedleast published
Citations8.4ktop 44% of dept.205th of 462
this lab
most citedleast cited
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