University of Florida · PharmacologyThe Hormone Dynamics Lab
Patrick Robert Griffin · Gainesville, Florida
Research Focus
Dr. Patrick Robert Griffin's research lab focuses on understanding how steroid hormone receptors, particularly the progesterone receptor and the retinoic acid receptor-related orphan receptor gamma (RORy), regulate various physiological processes. The lab uses advanced techniques like Cryo-EM and mass spectrometry to uncover the structural dynamics and activities of these receptors in complex with co-regulatory proteins and DNA. By elucidating the mechanistic details of receptor action, the lab aims to develop targeted therapies for diseases that involve these crucial proteins.
steroid hormone receptorsprogesterone receptorRORystructural dynamicsligand-dependent activation
Research Aims
3AIM 01Determine the high-resolution structure of the progesterone receptor complexed with co-activators and DNA.
AIM 02Map the conformational dynamics of the progesterone receptor using advanced structural techniques.
AIM 03Investigate how ligands influence the activity and interactions of RORy in full-length receptor context.
Skills the Lab Values
Cryo-electron microscopycrosslinking mass spectrometryhydrogen-deuterium exchangeprotein modelingfunctional mutagenesis