University of Florida · GeneticsRanum Lab
Laura P.W Ranum · Gainesville, Florida
Research Focus
Dr. Laura P.W. Ranum's lab focuses on understanding diseases caused by repetitive DNA sequences, particularly how certain proteins related to these sequences (called RAN proteins) may contribute to neurodegenerative disorders like Huntington's disease and spinocerebellar ataxias. The lab uses advanced techniques to explore the effects of these RAN proteins on cells and developing potential treatments to inhibit their harmful effects.
RAN proteinsHuntington's diseasespinocerebellar ataxiaprotein synthesisrepeat expansion disorders
Research Aims
3AIM 01Test the role of RAN proteins in spinocerebellar ataxias caused by repeat expansion mutations.
AIM 02Evaluate if PKR inhibition can reduce RAN protein levels and improve conditions in cell models.
AIM 03Investigate the impact of RAN proteins on disease phenotypes in mouse models.
Skills the Lab Values
cell cultureinduced pluripotent stem cellsgenetic engineeringAAV vector designanimal modelsRNA analysisCRISPR/Cas technologyimmunohistochemistrydrug development
Output against the department
Publications157top 49% of dept.127th of 259
this lab
most publishedleast published
Citations17ktop 34% of dept.88th of 259
this lab
most citedleast cited
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