Augusta University · BiologyNotch Signaling and Mechanosensitivity Lab
Paul Langridge · Augusta, Georgia
Research Focus
Dr. Paul Langridge's lab at Augusta University explores how mechanical forces activate the Notch signaling pathway, which is crucial for cell communication during development and disease. By studying Drosophila models, the lab examines the role of specific proteins, like Epsin, in the endocytosis process of Notch ligands. The research aims to uncover new insights into how disruptions in this process can lead to various human health issues, including cancers and other disorders.
Notch signalingendocytosisEpsinmechanosensitivityDrosophilacell communicationprotein interactionscancer research
Research Aims
5AIM 01Investigate the role of Epsin in Notch ligand endocytosis.
AIM 02Characterize the mechanical force required for Notch activation.
AIM 03Study alternative endocytic routes for Notch ligands in vivo.
AIM 04Examine the endocytic behavior of mechanosensitive ligands.
AIM 05Identify implications of Notch signaling dysregulation for human health.
Skills the Lab Values
cell cultureDrosophila geneticsbiochemical assaysprotein purificationlive imagingClathrin-mediated endocytosismicroscopyCRISPR gene editingdata analysis using R
Output against the department
Publications19bottom 2% of dept.1,010th of 1,033
this lab
most publishedleast published
Citations572bottom 2% of dept.1,008th of 1,033
this lab
most citedleast cited
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