University of Pennsylvania · BiologyPowell Immunotherapy Lab
Daniel J. Powell · Philadelphia, Pennsylvania
Research Focus
Dr. Daniel J. Powell's lab focuses on developing advanced CAR T cell therapies for treating solid tumors, particularly ovarian cancer. Their innovative approach combines gene-engineered T cells with imaging techniques to monitor treatment effectiveness and adjust therapies as needed. This multidisciplinary effort aims to leverage the body's immune system to effectively target cancer cells while minimizing toxic side effects.
CAR T cellsovarian cancerimmunotherapytumor microenvironmentgene editing
Research Aims
5AIM 01Develop a novel CAR T cell therapy specifically targeting folate receptor-alpha in ovarian cancer.
AIM 02Create imaging-enabled CAR T cells that allow for real-time monitoring of therapy effectiveness.
AIM 03Investigate the role of tumor-associated macrophages in response to CAR T cell treatments.
AIM 04Test the safety and efficacy of the ImAC platform in clinical settings.
AIM 05Optimize preconditioning methods for enhancing CAR T cell therapy against solid tumors.
Skills the Lab Values
cell cultureCAR T cell engineeringmolecular imagingsmall animal modelsflow cytometry
Output against the department
Publications268top 22% of dept.228th of 1,033
this lab
most publishedleast published
Citations15ktop 26% of dept.265th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.