Thomas Jefferson University · BiochemistryMitochondrial Dynamics and Function Lab
Dmitry Temiakov · Philadelphia, Pennsylvania
Research Focus
Dr. Dmitry Temiakov's lab focuses on understanding how our cells replicate and transcribe mitochondrial DNA, which is critical for energy production and overall cell function. The lab investigates the structures and mechanisms of dedicated enzymes that carry out these processes, aiming to unveil insights that could help in treating diseases associated with mitochondrial dysfunction. This research not only enhances our basic understanding of cellular biology but also contributes to addressing degenerative diseases linked to aging and mitochondrial mutations.
mitochondrial DNADNA replicationRNA transcriptionCryoEMDNA repair
Research Aims
4AIM 01Investigate the structure of mitochondrial RNA polymerase and its role in transcription.
AIM 02Determine the mechanism of mitochondrial DNA replication and the function of enzymes involved.
AIM 03Elucidate the biochemical pathways for DNA repair in human mitochondria.
AIM 04Explore the interactions between transcription and repair processes in mitochondrial DNA.
Skills the Lab Values
Cryo-electron microscopy (CryoEM)Molecular cloningBiochemical assaysMass spectrometryReconstitution of protein complexes
Output against the department
Publications65bottom 11% of dept.356th of 402
this lab
most publishedleast published
Citations3.7kbottom 19% of dept.326th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.