Indiana University-Purdue University-Indianapolis · Biomedical Engineering · PharmacologyOblak Lab
Adrian Lynn Oblak · Indianapolis, Indiana
Research Focus
Dr. Adrian Lynn Oblak's research lab focuses on understanding how environmental factors, particularly air pollution and certain fungi, influence the development and progression of Alzheimer's disease (AD). The lab investigates the role of peripheral immune cells, which are crucial in responding to pollutants, in exacerbating AD neuropathology. Through their studies, they aim to identify potential biological mechanisms that connect lung health and brain function, with the goal of finding ways to mitigate the impacts of these exposures on Alzheimer's disease.
Alzheimer's diseaseair pollutionimmune responseneuroinflammationfungal exposureLung-Brain Axismicrogliadementiaenvironmental risk factors
Research Aims
5AIM 01Define the role of CXCR2 in ozone-induced neuroimmune response.
AIM 02Examine the effect of ozone on microglial function related to amyloid pathology.
AIM 03Investigate how Aspergillus versicolor affects neuroinflammation and amyloid plaque formation.
AIM 04Explore the role of IL-5 in pulmonary immune responses in Alzheimer's disease.
AIM 05Assess the influence of TREM2 in neuroinflammation after exposure to environmental pollutants.
Skills the Lab Values
animal modelscell culture techniquesimmunohistochemistryflow cytometryRNA sequencingmolecular biology techniquespulmonary function testsdata analysis with R or Pythonbiostatistics
Output against the department
Publications1bottom 1% of dept.1,055th of 1,056
this lab
most publishedleast published
Citations0bottom 1% of dept.1,055th of 1,056
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.