Rutgers University-New Brunswick · BiologyThe Dendritic Dynamics Lab
Yosuke Kumamoto · New Brunswick, New Jersey
Research Focus
Dr. Yosuke Kumamoto's lab at Rutgers focuses on understanding a specific type of immune cell called conventional dendritic cells (cDC2s) and their role in allergic responses and autoimmune diseases. The team is investigating how different subsets of these cells are formed in various organs and how they contribute to immune responses to allergens and parasites. Their work aims to uncover the mechanisms behind the differentiation of these immune cells, which could lead to new treatments for allergies and related health issues.
conventional dendritic cellsimmune responsetype 2 inflammationallergieshelminth parasitescell differentiationtranscription factorsimmunologytherapeutic targets
Research Aims
5AIM 01Identify the precursor cell populations that give rise to CD301b+ DCs in peripheral organs.
AIM 02Elucidate the role of IRF4 and CD301b+ DC-specific transcription factors in their differentiation.
AIM 03Explore the context-dependent mechanisms of cDC2 subset differentiation.
AIM 04Investigate the functional roles of different cDC2 subsets in immune responses to allergens.
AIM 05Evaluate potential therapeutic targets for allergies and autoimmune diseases.
Skills the Lab Values
cell cultureCRISPR/Cas technologysingle-cell RNA sequencingtranscription factor analysisfluorescence-activated cell sortingflow cytometrymRNA expression analysismouse modelsdata analysis
Output against the department
Publications39bottom 7% of dept.959th of 1,033
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.790th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.