University of California-San Diego · EngineeringMali Lab
Prashant Mali · La Jolla, California
Research Focus
Dr. Prashant Mali's lab at UC San Diego focuses on developing advanced combinatorial genetic screening technologies using CRISPR systems. The aim is to understand how multiple genes interact and how these interactions influence cellular behavior and disease. By creating platforms that allow researchers to perform intricate genetic experiments more efficiently, the lab hopes to contribute to both basic biological understanding and therapeutic development.
CRISPRgenetic screeningcell fate specificationmachine learningtherapeutics development
Research Aims
5AIM 01Develop a massively multiplexed combinatorial genetic screening platform.
AIM 02Map genetic interactions that drive cellular and organismal phenotypes.
AIM 03Apply advanced computational methods to analyze combinatorial screening data.
AIM 04Predict gene interactions beyond direct experimental measurements.
AIM 05Generate new reagents and data useful for basic science and therapeutics discovery.
Skills the Lab Values
CRISPRcell culturecomputational biologydata analysisgenetic engineering
Output against the department
Publications232top 40% of dept.110th of 278
this lab
most publishedleast published
Citations25ktop 13% of dept.37th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.