Augusta University · PhysiologyPreeclampsia Research Lab
Jessica L. Faulkner · Augusta, Georgia
Research Focus
Dr. Jessica L. Faulkner's lab at Augusta University focuses on understanding preeclampsia, a serious pregnancy complication marked by high blood pressure. The research examines how the hormone leptin, which is found in elevated levels in preeclampsia patients, affects maternal and fetal health by causing cardiovascular issues. By using mouse models, the lab investigates the mechanisms underlying leptin's role in this condition, with the aim of developing better treatments.
preeclampsialeptincardiovascular diseaseplacental dysfunctionhypertensionmaternal healthfetal growth restrictionendothelial dysfunctionadipokines
Research Aims
4AIM 01Investigate how placental ischemia increases leptin levels through sFlt-1 in preeclampsia.
AIM 02Examine the role of endothelial leptin receptors in mediating hypertension and fetal growth restriction.
AIM 03Determine the impact of endothelin-1 in leptin-induced endothelial dysfunction in pregnant mice.
AIM 04Evaluate the potential of targeting leptin regulatory pathways for therapeutic purposes in preeclampsia.
Skills the Lab Values
mouse modelsendothelial cell culturehormone assaysvascular function testsWestern blottingPCRblood pressure monitoringimmunohistochemistryCRISPR
Output against the department
Publications126bottom 39% of dept.174th of 286
this lab
most publishedleast published
Citations3.0kbottom 24% of dept.217th of 286
this lab
most citedleast cited
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