University of Miami · BiologyHIV Immunotherapy Innovations Lab
Sebastian Patrick Fuchs · Coral Gables, Florida
Research Focus
Dr. Sebastian Patrick Fuchs runs a research lab at the University of Miami School of Medicine focusing on innovative ways to enhance the immune response to HIV treatment using advanced virus-mediated gene delivery systems. His lab is pioneering strategies to prevent the immune system from rejecting therapeutic antibodies delivered through adeno-associated viruses (AAV). This research aims to develop an effective treatment for HIV that could offer long-term solutions without the need for continuous medication.
HIVgene therapyAAVbroadly neutralizing antibodiesimmunomodulatory drugsimmune tolerancemRNAserum monitoringvaccine development
Research Aims
4AIM 01Develop strategies to prevent host immune responses toward AAV-delivered antibodies.
AIM 02Establish a drug regimen to induce immune tolerance in rhesus monkeys.
AIM 03Monitor antibody levels and immune responses in treated and control groups over time.
AIM 04Explore mRNA delivery systems to enhance tolerance against therapeutic antibodies.
Skills the Lab Values
Adeno-associated virus (AAV) handlingImmunomodulatory drug administrationAnimal models (rhesus monkeys)Serum analysis for antibodiesNucleoside-modified mRNA techniquesIntramuscular injection techniquesControl group assignmentExperimental design in clinical researchStatistical analysis of biomedical data