University of Alabama at Birmingham · BiologyIntestinal Immunity and Inflammation Lab
Casey T Weaver · Birmingham, Alabama
Research Focus
Dr. Casey T. Weaver's lab at the University of Alabama at Birmingham focuses on understanding how the immune system protects the intestines, particularly in the context of inflammatory bowel disease and neonatal health. The lab investigates the roles of specialized immune cells and cytokines in defending against harmful bacteria, maintaining intestinal health, and preventing infections in early life. Their research aims to uncover new treatment strategies for conditions like inflammatory bowel disease and late-onset sepsis in neonates.
intestinal immunityinflammatory bowel diseasecytokinesmicrobiomesepsis preventionTreg cellsimmune signalinghost defensebacterial infection
Research Aims
5AIM 01Investigate how immune cells coordinate to protect the intestinal barrier from pathogens.
AIM 02Identify mechanisms that regulate the development and function of effector Treg cells in the intestine.
AIM 03Elucidate how neonatal dysbiosis contributes to late-onset sepsis in premature infants.
AIM 04Analyze the role of IL-22 in intestinal inflammation and cancer.
AIM 05Explore therapeutic strategies to enhance intestinal immune responses.
Skills the Lab Values
cell culturemouse modelsflow cytometryWestern blotanalytical techniquesRNA sequencingimmunoassaysgene editing (CRISPR)cytokine profiling
Output against the department
Publications334top 15% of dept.156th of 1,033
this lab
most publishedleast published
Citations37ktop 8% of dept.82nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.