University of Texas Southwestern Medical Center · NeuroscienceDiamond Neurodegeneration Lab
Marc I Diamond · Dallas, Texas
Research Focus
Dr. Marc I. Diamond's lab at UT Southwestern focuses on understanding how tau proteins contribute to neurodegenerative diseases like Alzheimer's. They explore how tau protein aggregates spread between brain cells and how these aggregates can enter cells, which might help in developing new therapeutic strategies. The lab combines mechanisms of protein binding and cellular uptake in their research to unravel the complexities of tau-related pathology.
Alzheimer's Diseasetau proteinneurodegenerationcell uptakeheparan sulfate proteoglycanspathology propagationmouse modelsHSPGsprotein aggregates
Research Aims
4AIM 01Investigate the role of NDST isoforms in tau-induced neurodegeneration using mouse models.
AIM 02Determine how tau aggregates cross the cell membrane.
AIM 03Compare the uptake mechanisms of tau with other pathogenic proteins like alpha-synuclein and TDP-43.
AIM 04Explore the significance of heparan sulfate proteoglycans in the binding and propagation of tau pathology.
Skills the Lab Values
CRISPRmouse modelscell cultureimmunohistochemistryfluorescence microscopyprotein purificationendocytosis assaysRT-PCRtransfection techniques
Output against the department
Publications202top 37% of dept.245th of 671
this lab
most publishedleast published
Citations18ktop 24% of dept.159th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.