WMCWeill Medical College of Cornell University · Biomedical Engineering
Gabr Immunomodulation Lab
Moustafa Gabr · New York, New York
Research Focus
Dr. Moustafa Gabr's lab at Weill Medical College focuses on developing small molecule therapies to tackle challenging diseases like Alzheimer's, inflammatory bowel disease (IBD), and glioblastoma. They utilize an innovative platform to identify molecules that can modulate the immune response, aiming to enhance treatment efficacy and minimize side effects compared to traditional biologics. The lab emphasizes harnessing the power of small molecules to interact with key immune receptors to improve therapeutic outcomes.
Alzheimer's diseaseimmunomodulationglioblastomainflammatory bowel diseasesmall moleculesTREM2CD28ICOSSlit2/Robo
Research Aims
5AIM 01Develop small molecule TREM2 ligands to treat Alzheimer's disease
AIM 02Optimize small molecule inhibitors of CD28 and ICOS for inflammatory bowel disease therapy
AIM 03Investigate small molecule therapeutics targeting Slit2/Robo signaling in glioblastoma
AIM 04Evaluate pharmacokinetic profiles of optimized therapeutic leads
AIM 05Test small molecules in preclinical models for therapeutic validation.
Skills the Lab Values
cell cultureanimal modelspharmacokineticsbiophysical screeningdrug designvirtual screeningmolecular binding assaysimmunohistochemistryWestern blotting
Output against the department
Publications158bottom 35% of dept.386th of 595
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.522nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.