University of California-Berkeley · BiochemistryGrowth Regulation and Regeneration Lab
Iswar K. Hariharan · Berkeley, California
Research Focus
Dr. Iswar K. Hariharan's lab at UC Berkeley focuses on understanding how growth is regulated in living organisms, particularly through studying the development and regeneration of structures in fruit flies (Drosophila). By examining the genetic mechanisms involved during both normal growth processes and regenerative growth after injury, the lab seeks to uncover the critical interactions between different cell types. This research is vital for gaining insights into various medical conditions, including cancer and birth defects, which are influenced by growth abnormalities.
Drosophilaregenerative growthgenetic regulationsingle-cell transcriptomicscell proliferationmechanosensitive channelsHedgehog signalingcell-surface proteinsplanar cell polaritygrowth regulation
Research Aims
5AIM 01Identify gene regulatory networks essential for regenerative growth.
AIM 02Characterize genes that govern cell behavior during regeneration.
AIM 03Examine the role of ion channels in growth signaling pathways.
AIM 04Investigate how tissue damage affects overall organ development.
AIM 05Study the interactions between cell-surface proteins and their receptors.
Skills the Lab Values
single-cell RNA sequencingexperimental geneticsDrosophila embryo injectioncell culture techniquesgenetic screeningimmunohistochemistrymicroscopydata analysis in Rbioinformaticspopulation genetics
Output against the department
Publications126bottom 36% of dept.258th of 402
this lab
most publishedleast published
Citations11ktop 46% of dept.186th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.