University of Alabama at Birmingham · BiologyGlioma Precision Therapeutics Unit
Christopher Ryan Miller · Birmingham, Alabama
Research Focus
The Miller Lab focuses on developing new human glioma models to enhance precision treatment for brain tumors. They use advanced techniques to understand how these tumors function and resist therapies, helping to create targeted drug strategies. By collaborating with experts in various fields, the lab aims to improve options for patients suffering from gliomas, which are the most common and deadly brain cancer.
gliomaprecision therapeuticsEGFRdrug resistanceCRISPRpatient-derived modelskinomeproteomicspreclinical drug developmentbrain tumors
Research Aims
5AIM 01Develop genetically engineered glioma models to study EGFR mutations.
AIM 02Credential models against patient-derived xenografts and organoids using comprehensive molecular profiling.
AIM 03Assess therapeutic efficacy of targeted drugs on glioma models.
AIM 04Investigate mechanisms of drug resistance in gliomas.
AIM 05Create combination therapies to enhance the effectiveness of EGFR inhibitors.
Skills the Lab Values
CRISPR genome editingmass spectrometrynext-generation sequencingbiological modelingcell culturedrug testingRNA sequencingmouse modelstemporal kinase profilinggenomic analysis
Output against the department
Publications335top 15% of dept.155th of 1,033
this lab
most publishedleast published
Citations28ktop 12% of dept.129th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.