University of California-San Francisco · Biomedical EngineeringBarcellos-Hoff Lab
Mary Helen Barcellos-Hoff · San Francisco, California
Research Focus
Dr. Mary Helen Barcellos-Hoff's research lab focuses on innovative treatments for cancer using radiopharmaceutical therapy (RPT). By targeting transforming growth factor (TGF) activity, which is often dysregulated in cancer, her team aims to develop new theranostic approaches that can be applied across various types of tumors. Through preclinical cancer models, they investigate how RPT can be optimized for better efficacy and understanding of biological responses to radiation treatment.
radiopharmaceutical therapytheranostictransforming growth factorTGFpreclinical cancer modelsPET imagingradiobiologycancer treatmentimmunology
Research Aims
4AIM 01Develop a radiolabeled neutralizing antibody for TGF to visualize its activity in cancer models.
AIM 02Evaluate the dosimetry and pharmacokinetics of the TGF-targeted RPT in different cancer types.
AIM 03Establish mechanisms of radiation response variability in cancer models with different TGF activity levels.
AIM 04Investigate the relationship between radiation dose and TGF activity on tumor control and immune response.
Skills the Lab Values
PET imagingradiolabelingmouse modelscell culturedosimetrydrug kineticscancer biology techniquesradiobiology analysisisotope preparation
Output against the department
Publications431top 21% of dept.122nd of 595
this lab
most publishedleast published
Citations17ktop 22% of dept.132nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.