Washington University in St Louis · BiologyRandolph Lab
Gwendalyn J Randolph · Saint Louis, Missouri
Research Focus
Dr. Gwendalyn J Randolph's lab focuses on understanding and treating intestinal failure-associated liver disease (IFALD), especially in pediatric patients suffering from short gut syndrome and inflammatory bowel diseases. The research involves investigating how specific signaling pathways in the intestines and lymphatic systems contribute to these conditions and exploring potential therapeutic approaches using novel compounds. By combining studies in mouse models and piglet models, the lab aims to translate their findings into effective treatments for children.
short gut syndromeintestinal failureliver diseaseinflammatory bowel diseaselymphatic transporttertiary lymphoid organsLXR agonismprotein losing enteropathypediatric research
Research Aims
5AIM 01Investigate the role of LXR agonism in protecting the liver from damage caused by intestinal failure.
AIM 02Study the mechanisms of lymphatic transport alteration in inflammatory bowel disease.
AIM 03Define how tertiary lymphoid organs contribute to fluid dynamics in Crohn's disease.
AIM 04Evaluate therapeutic approaches to prevent liver fibrosis in short gut syndrome models.
AIM 05Understand the relationship between lymphatic flow and protein losing enteropathy.
Skills the Lab Values
mouse modelspiglet modelsoral drug deliverylymphatic imagingmolecular biology techniquesprotein analysishistologyimmunofluorescencecell culture
Output against the department
Publications329top 16% of dept.163rd of 1,033
this lab
most publishedleast published
Citations50ktop 5% of dept.56th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.