Tufts University · ChemistryKritzer Therapeutics Lab
Joshua A Kritzer · Medford, Massachusetts
Research Focus
The Kritzer lab at Tufts University focuses on developing new therapeutic methods to combat late-stage cancers. Their research revolves around inhibiting autophagy, a process that degrades proteins within cells, which can be detrimental when cancers use it to survive. They are creating novel inhibitors and chimeras to selectively target and degrade key proteins involved in this process. Additionally, the lab is working to improve how large-molecule drugs penetrate cells to enhance their effectiveness.
autophagycancer therapyprotein degradationchimerasdrug developmentcell penetrationCRISPRsmall moleculestherapeutics
Research Aims
5AIM 01Develop novel inhibitors of autophagy targeting the LC3/GABARAP protein family.
AIM 02Create autophagy-targeting chimeras for selective protein degradation.
AIM 03Enhance understanding of how large-molecule therapeutics penetrate cells.
AIM 04Establish new assays to measure cytosolic penetration of therapeutics.
AIM 05Use pooled CRISPR screens to identify components mediating endosomal escape.
Skills the Lab Values
cell cultureCRISPR screeningprotein expressionmolecular evolutionhigh-throughput screeninganalytical assayspeptide synthesisdata analysisdrug design
Output against the department
Publications87bottom 18% of dept.177th of 216
this lab
most publishedleast published
Citations3.2kbottom 21% of dept.171st of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.