Washington University in St Louis · BiologyZaher Ribosome Lab
Hani Zaher · Saint Louis, Missouri
Research Focus
Dr. Hani Zaher's lab at Washington University studies how cells respond to stress by examining the ribosome's role in managing and repairing RNA during damage. They explore how ribosomes signal for quality control and stress responses, helping to maintain cellular health. Their research aims to better understand how these mechanisms support cellular functions and protect against diseases like cancer and neurodegeneration.
ribosomestress responseRNA damagequality controlcell signalinggene expressiontranslational machinerydiseasetranscription regulationmRNA
Research Aims
5AIM 01Investigate how ribosomes act as sensors for stress signals in cells.
AIM 02Examine the mechanisms by which cells degrade damaged ribosomes.
AIM 03Explore the interaction between RNA damage and DNA damage response pathways.
AIM 04Identify how conservation of translation and transcription processes works to protect cells.
AIM 05Understand the implications of ribosome quality control in disease states.
Skills the Lab Values
RNA sequencingmolecular biology techniquescell cultureprotein analysisWestern blotgenomic editingbioinformaticsdata analysis with Pythonmicroscopyexperimental design
Output against the department
Publications112bottom 39% of dept.630th of 1,033
this lab
most publishedleast published
Citations4.6kbottom 36% of dept.665th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.