Yale University · GeneticsLim Lab
Janghoo Lim · New Haven, Connecticut
Research Focus
Dr. Janghoo Lim's lab at Yale University focuses on understanding the causes and mechanisms behind neurodegenerative diseases, such as Alzheimer's and spinocerebellar ataxia. They study how specific proteins and genetic mutations affect brain cells, particularly oligodendrocytes, which are vital for nervous system health. Their research aims to reveal new pathways for potential therapies by exploring how these proteins can be targeted to slow down or prevent disease progression.
neurodegenerative diseasesATXN1olgodendrocyteslysosome biogenesisTDP-43 proteinopathyamyotrophic lateral sclerosisAlzheimer's diseasefrontotemporal dementiacell differentiationgene regulation
Research Aims
3AIM 01Investigate how ATXN1 influences oligodendrocyte function in neurodegenerative diseases.
AIM 02Examine the mechanisms by which ATXN1 mutations affect brain cell types beyond neurons.
AIM 03Understand the role of Nemo-like kinase in regulating lysosome function in neurodegeneration.
Skills the Lab Values
animal modelsgenetic manipulationin vitro techniquesimmunohistochemistryWestern blottingcell culturePCRRNA extractionfluorescence microscopybehavioral assays
Output against the department
Publications60bottom 13% of dept.226th of 259
this lab
most publishedleast published
Citations5.5kbottom 31% of dept.179th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.