University of California-Los Angeles · NeuroscienceTau Pathology Research Unit
Chao Peng · Los Angeles, California
Research Focus
The lab led by Chao Peng at UCLA focuses on understanding how certain chemical changes to tau proteins, called post-translational modifications, can influence the spread of tau-related diseases such as Alzheimer's. Their research is crucial for developing new therapies to slow down the progression of these neurodegenerative conditions. By studying tau from different disease states and using advanced techniques, they aim to uncover novel ways to interfere with tau transmission in the brain.
tauopathiesAlzheimer's diseasepost-translational modificationsprotein transmissionneurology
Research Aims
5AIM 01Identify and quantify post-translational modifications of soluble tau in Alzheimer's and other tauopathies.
AIM 02Explore the effects of soluble tau modifications on pathological tau amplification.
AIM 03Investigate how different brain regions and cell types respond to soluble tau modifications.
AIM 04Study the influence of the cellular environment on pathological tau amplification.
AIM 05Evaluate the effects of soluble tau modifications on tau amplification in mouse models.
Skills the Lab Values
LC-MS/MSmouse modelscell cultureimmunocytochemistrybiochemical assays
Output against the department
Publications422top 14% of dept.94th of 671
this lab
most publishedleast published
Citations22ktop 18% of dept.123rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.