University of Pittsburgh-Pittsburgh Campus · PharmacologyMetabolic Liver Research Unit
Mark T. Miedel · Pittsburgh, Pennsylvania
Research Focus
Dr. Mark T. Miedel's lab focuses on improving treatment strategies for metabolic dysfunction associated with fatty liver disease (MAFLD). They use innovative technology to create a human-like liver model, allowing them to study how specific genetic variations affect the disease and test potential new medicines. By mimicking human liver function, the lab aims to understand the mechanisms that contribute to MAFLD and identify more effective therapeutic options.
MAFLDiPSCdrug discoverymicrophysiology systemgenetic variants
Research Aims
3AIM 01Develop a biomimetic liver model using iPSC-derived cells to study normal liver and MAFLD progression.
AIM 02Investigate drug responses in liver cells with genetic variants linked to MAFLD.
AIM 03Identify new therapeutic strategies targeting disease mechanisms through experimental testing.
Skills the Lab Values
cell culturegenome editingpharmacodynamicshigh-throughput drug screeningbioinformatics analysis
Output against the department
Publications43bottom 4% of dept.442nd of 462
this lab
most publishedleast published
Citations840bottom 3% of dept.449th of 462
this lab
most citedleast cited
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