University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyThomas Lab
Gary Thomas · Pittsburgh, Pennsylvania
Research Focus
Dr. Gary Thomas's lab at the University of Pittsburgh is focused on understanding how specific genetic mutations impact neuronal function and behavior. By studying disorders linked to mutations in the PACS1 and PACS2 genes, the lab aims to unravel the cellular mechanisms that lead to neurodevelopmental issues like intellectual disability, epilepsy, and autism. This research could pave the way for developing new therapies for these debilitating conditions.
PACS1 SyndromePACS2 Syndromeneurodevelopmental disordersneurotransmissioncalcium signalingdendritic arborizationepilepsyautismcellular traffickingbehavioral deficits
Research Aims
5AIM 01Investigate how the R203W mutation in PACS1 alters its structure and function.
AIM 02Determine the role of PACS1R203W and HDAC6 in dendrite arborization and synaptic transmission.
AIM 03Examine how PACS2E209K affects ER-mitochondria calcium transfer and neuronal metabolism.
AIM 04Analyze the impact of PACS2E209K on neurotransmission and behavior.
AIM 05Explore potential therapeutic targets for PACS1 and PACS2 syndrome.
Skills the Lab Values
biophysical analysiselectrophysiologycell culturelive-cell imaginggenetic manipulationanimal modelsbiochemical assaysmetabolic profilingbehavioral testingimmunohistochemistry
Output against the department
Publications106bottom 38% of dept.300th of 486
this lab
most publishedleast published
Citations10ktop 36% of dept.177th of 486
this lab
most citedleast cited
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