Protein Interaction and Modification Lab
Farren J. Isaacs · New Haven, Connecticut
Yale University · Biochemistry
Research focus
Farren J. Isaacs' lab at Yale University focuses on understanding how proteins interact with each other and how their functions are modified by chemical changes called post-translational modifications (PTMs). By engineering bacteria to produce proteins with specific modifications, the lab aims to uncover the role of these modifications in crucial cellular processes and disease states. This pioneering work could lead to the development of new therapeutic strategies targeting diseases linked to protein interactions.
post-translational modificationsprotein-protein interactionssynthetic biologygenome engineeringdrug discoveryrecoded organismsE. coli
Research aims
3AIM 01Utilize a recoded organism to encode specific post-translational modifications in proteins.
AIM 02Develop a method to identify protein binders that interact based on their PTMs.
AIM 03Engineer small protein binders to target disease-relevant phosphorylated proteins.
Skills the lab values
protein engineeringsynthetic biology techniquesE. coli culturehigh-throughput screeningmolecular cloningCRISPRbiochemical assaysprotein purificationdata analysis in genomicsbioinformatics
Output against the department
95publicationsbottom 23% of the department311th of 402
most publishedleast published
12kcitationstop 42% of the department169th of 402
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.