Pennsylvania State University-Main Campus · BiochemistryJose Lab
Joyce Jose · University Park, Pennsylvania
Research Focus
Dr. Joyce Jose's lab at Penn State University focuses on understanding how the Zika virus spreads from mother to fetus, particularly during pregnancy. The lab is exploring a cellular structure known as tunneling nanotubes, which may help the virus transmit between cells in the placenta. By studying these mechanisms, the lab aims to find new ways to prevent serious birth defects linked to Zika virus infections.
Zika virustunneling nanotubesmaternal-fetal transmissionvirus-host interactionsplacental health
Research Aims
5AIM 01Investigate the role of ZIKV non-structural protein 1 in tunneling nanotube formation.
AIM 02Evaluate how tunneling nanotubes facilitate ZIKV transmission in placental cells.
AIM 03Determine the impact of tunneling nanotubes on ZIKV pathogenesis during pregnancy.
AIM 04Explore the transport of mitochondria via tunneling nanotubes in infected cells.
AIM 05Identify key genomic pathways involved in tunneling nanotube formation in placental tissues.
Skills the Lab Values
confocal microscopyflow cytometryRNA transport analysiscell culture techniquesmouse models of infection
Output against the department
Publications56bottom 10% of dept.362nd of 402
this lab
most publishedleast published
Citations4.5kbottom 26% of dept.297th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.