University of Pennsylvania · Microbiology & ImmunologyCholera and Gut Interactions Lab
Jun Zhu · Philadelphia, Pennsylvania
Research Focus
The lab led by Jun Zhu at the University of Pennsylvania focuses on understanding how the bacterium Vibrio cholerae interacts with the gut microbiome and human mucins during infection. The research explores how variances in gut microbiota influence V. cholerae colonization and the disease outcomes in individuals. It aims to uncover the mechanisms through which bacterial enzymes interact with mucus layers to modulate infections, which may lead to novel treatments for cholera.
Vibrio choleraegut microbiotamucinsinfectious diseasescholera
Research Aims
4AIM 01Elucidate mechanisms of mucin-dependent interactions of V. cholerae with gut microbes.
AIM 02Examine how gut microbiota structure influences mucin and TagA-dependent disease phenotypes.
AIM 03Determine the role of TagA-microbiota interactions in host mucin production and metabolism.
AIM 04Investigate spatial specificity in microbiota-driven V. cholerae disease outcomes.
Skills the Lab Values
in vivo animal modelsex vivo tissue culturemolecular cloningmicrobiome analysisproteomicsunderstanding bacteria-host interactionscell culture techniquesbioinformaticsmetabolomics
Output against the department
Publications338top 13% of dept.64th of 486
this lab
most publishedleast published
Citations37ktop 7% of dept.33rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.