Icahn School of Medicine at Mount Sinai · NeuroscienceMyeloid Immune Research Lab
Towfique Raj · New York, New York
Research Focus
Dr. Towfique Raj's research lab focuses on understanding the role of immune cells, particularly myeloid cells, in Parkinson's Disease (PD). By analyzing genetic variants and their effects on these cells, the lab aims to bridge the gap between genetic associations and the biological mechanisms that lead to PD. Their work involves advanced techniques in transcriptomics and proteomics to uncover how these immune cells function differently in individuals with PD compared to healthy individuals, potentially leading to breakthroughs in treatment.
Parkinson's Diseasemyeloid cellsgenetic variantstranscriptomicsproteomicsimmune functionautophagymitochondrial functionclinical data integration
Research Aims
3AIM 01Generate transcriptome and proteome profiles from monocytes of Parkinson's Disease patients and controls.
AIM 02Characterize the transcriptome of primary microglia in post-mortem Parkinson's Disease brains.
AIM 03Functionally analyze the immune-related activities of monocytes and microglia linked to PD-related genetic variants.
Skills the Lab Values
bulk and single cell RNA sequencingdata integration techniquesproteomicsbioinformaticsclinical sample collectionmicroglia cultureflow cytometrygene expression analysismultivariate analysis
Output against the department
Publications221top 33% of dept.224th of 671
this lab
most publishedleast published
Citations22ktop 18% of dept.122nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.