University at Buffalo · BiologyVascular Mechanics and Smooth Muscle Unit
Yongho Bae · Buffalo, New York
Research Focus
Dr. Yongho Bae's lab focuses on understanding how the stiffness of blood vessels influences the behavior of vascular smooth muscle cells, which play a crucial role in cardiovascular diseases. The research aims to uncover the molecular mechanisms behind this relationship, particularly the role of a protein called survivin. By using advanced cell culture techniques and mouse models, the lab seeks to identify new therapeutic targets to prevent vascular-related conditions and improve heart health.
vascular smooth muscle cellsarterial stiffnesscardiovascular diseaseextracellular matrixneointima formationsurvivin3D cell culturebiomechanics
Research Aims
3AIM 01Investigate how arterial ECM stiffness affects VSMC migration and proliferation.
AIM 02Examine the influence of pathological ECM stiffness on neointima formation in vitro.
AIM 03Determine the role of survivin in regulating ECM production and arterial stiffness in vivo.
Skills the Lab Values
3D cell culturemicroscopymouse modelsRNA sequencingbiochemical analysishistologybiomechanical testingfluorescent in situ hybridization
Output against the department
Publications80bottom 23% of dept.791st of 1,033
this lab
most publishedleast published
Citations1.6kbottom 10% of dept.931st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.