EUEmory University · Biochemistry
RiboShield Lab
Graeme L Conn · Atlanta, Georgia
Research Focus
Dr. Graeme L. Conn's lab at Emory University focuses on understanding how bacterial enzymes modify ribosomal RNA to confer antibiotic resistance. By investigating the molecular details of these modifications, the lab aims to uncover new methods to combat bacterial infections and prolong the effectiveness of existing antibiotics.
antibiotic resistanceribosomal RNAmethyltransferasesbacterial infectionsantibiotic modification
Research Aims
3AIM 01Investigate the mechanisms of action of methyltransferases involved in antibiotic resistance.
AIM 02Characterize the molecular basis of ribosome recognition by intrinsic rRNA methyltransferase enzymes.
AIM 03Assess how rRNA methylation affects bacterial sensitivity to aminoglycosides and ribosome function.
Skills the Lab Values
RNA purificationenzyme assayshigh-resolution structural analysiscryoelectron microscopymolecular modelingbacterial culturegenetic engineeringdata analysis with Python
Output against the department
Publications153bottom 43% of dept.228th of 402
this lab
most publishedleast published
Citations3.3kbottom 15% of dept.342nd of 402
this lab
most citedleast cited
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