University of North Carolina at Chapel Hill · PhysiologyPrenatal Alcohol Research Laboratory
Scott Parnell · Chapel Hill, North Carolina
Research Focus
Dr. Scott Parnell's lab at the University of North Carolina Chapel Hill focuses on understanding the effects of ethanol (alcohol) exposure during pregnancy, particularly its role in causing developmental disorders. The research explores how prenatal alcohol impacts cellular processes, genetics, and signaling pathways, which can lead to Fetal Alcohol Spectrum Disorders (FASD). By using advanced models like mice and zebrafish, the lab aims to uncover the molecular mechanisms behind these disorders and identify genetic factors that influence individual susceptibility.
Fetal Alcohol Spectrum Disorderethanol exposuregeneticscell signalingprimary ciliazebrafish modelsmouse modelshigh-throughput screening
Research Aims
3AIM 01Investigate how ethanol disrupts transport mechanisms within primary cilia.
AIM 02Explore the effects of ethanol on G-protein coupled receptors linked to primary cilia.
AIM 03Identify novel pathways and candidate genes associated with ethanol-induced developmental disorders.
Skills the Lab Values
CRISPR/Cas9 gene editingRNA sequencing (RNA-Seq)mouse geneticszebrafish phenotypingcell cultureapoptosis assaysmicrotubule transport studiesbioinformaticshigh-throughput drug screening
Output against the department
Publications82bottom 20% of dept.229th of 286
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.234th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.