University of Michigan-Ann Arbor · PharmacologyThe Insulin Insight Lab
Julien Albert Sebag · Ann Arbor, Michigan
Research Focus
Dr. Julien Albert Sebag's lab at the University of Michigan focuses on understanding how the protein Unc119b affects glucose regulation and insulin sensitivity. By exploring new compounds that boost insulin effectiveness while avoiding significant side effects, the lab seeks to develop better treatments for type II diabetes. Their innovative research combines live cell imaging and genetic models to uncover the mechanisms behind insulin resistance.
insulin sensitivitytype II diabetesglucose homeostasisUnc119bGLUT4 translocationdrug discoveryanimal models cardiovascular health
Research Aims
3AIM 01Investigate the role of Unc119b in glucose homeostasis across different tissues.
AIM 02Determine the protective effects of C59 and Unc119b deletion on pancreatic beta-cells.
AIM 03Identify interacting proteins and the molecular mechanisms of Unc119b in regulating GLUT4.
Skills the Lab Values
mouse modelsinsulin signaling assaysglucose tolerance testslive-cell imagingWestern blotgenetic engineeringthermofluor assaysmetabolic profilingprotein interaction analysis
Output against the department
Publications51bottom 7% of dept.429th of 462
this lab
most publishedleast published
Citations1.6kbottom 9% of dept.419th of 462
this lab
most citedleast cited
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