University of Pennsylvania · EngineeringGao Genome Lab
Xue Gao · Philadelphia, Pennsylvania
Research Focus
Dr. Xue Gao's lab at the University of Pennsylvania focuses on advancing techniques for precise genome editing, particularly in the context of cardiac diseases like hypertrophic cardiomyopathy (HCM). Through innovative approaches, they are developing controllable base editors that aim to correct genetic mutations with minimal off-target effects, ultimately offering new potential treatments for various conditions. The research explores new methods of delivering these genetic tools to ensure effective and safe applications in living organisms.
genome editinghypertrophic cardiomyopathybase editorsspatiotemporal controlgene therapy
Research Aims
5AIM 01Develop chemically inducible split base editors for precise genome editing
AIM 02Reduce off-target effects of genome editing tools
AIM 03Apply base editing techniques to correct MYBPC3 mutations
AIM 04Test the efficacy of base editors in animal models
AIM 05Enhance the delivery mechanisms of genome editors for therapeutic use
Skills the Lab Values
CRISPRAAV deliveryin vivo modelsdrug formulationmolecular cloning
Output against the department
Publications124bottom 27% of dept.202nd of 278
this lab
most publishedleast published
Citations6.4kbottom 48% of dept.145th of 278
this lab
most citedleast cited
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