University of California-San Francisco · BiologyThe Tolerance Lab
Adrian Erlebacher · San Francisco, California
Research Focus
Dr. Adrian Erlebacher's lab at UCSF focuses on understanding how the fetus and placenta evade rejection by the maternal immune system. They investigate the role of glycosylated proteins on the surface of the placenta in modulating immune responses, which has implications for pregnancy complications like preeclampsia and miscarriage. Their research combines animal models and human samples to explore these mechanisms and aims to open new avenues for developing immune tolerance therapies.
immune toleranceglycobiologypregnancy complicationsplacentaimmunology
Research Aims
3AIM 01Evaluate the role of glycan-specific antibodies in mediating maternal immune responses to placental antigens.
AIM 02Determine the features of trophoblast glycans that impart immunosuppressive properties.
AIM 03Investigate the behavior of tissue resident memory T cells in the decidua regarding trophoblast antigens.
Skills the Lab Values
mass spectrometrymouse modelscell cultureimmunohistochemistryflow cytometry
Output against the department
Publications58bottom 14% of dept.884th of 1,033
this lab
most publishedleast published
Citations6.3kbottom 46% of dept.561st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.