University of South Florida · PhysiologyThe Laminin Lab
Yao Yao · Tampa, Florida
Research Focus
Dr. Yao Yao's lab focuses on how a specific protein called pericytic laminin affects brain health, particularly in relation to Alzheimer's disease. They study its role in maintaining the blood-brain barrier, regulating blood flow in the brain, and preventing nerve damage. The goal is to uncover new ways to treat age-related brain disorders by understanding these mechanisms better.
Alzheimer's diseaseneurovascular functionblood-brain barrierneuronal survivallaminincerebral blood flowpericytesneurodegenerationmolecular targets
Research Aims
4AIM 01Investigate how loss of pericytic laminin affects blood-brain barrier integrity.
AIM 02Examine the impact of pericytic laminin on cerebral blood flow.
AIM 03Determine how loss of pericytic laminin influences brain influx and efflux functions.
AIM 04Explore the role of pericytic laminin in neuronal injury and neurodegeneration.
Skills the Lab Values
cell culturequantitative autoradiographytwo-photon imagingin vitro assaysfluorescent labeling techniquesWestern blottingmouse modelsbiochemical assaysmolecular biology techniques
Output against the department
Publications875top 1% of dept.4th of 286
this lab
most publishedleast published
Citations24ktop 10% of dept.29th of 286
this lab
most citedleast cited
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