University of California-Irvine · PharmacologyInnovative Drug Discovery Technologies Lab
Brian M Paegel · Irvine, California
Research Focus
Dr. Brian Paegel's lab focuses on developing innovative technologies for drug discovery by utilizing DNA-encoded libraries. They aim to create more effective methods to identify drug candidates that can target challenging protein interfaces, a vital step in the quest for new therapies. By employing advanced techniques like microfluidics and automated processes, the lab seeks to make drug discovery more accessible and efficient, potentially revolutionizing how new treatments are developed for various diseases.
drug discoveryDNA-encoded librariesmicrofluidicsprotein-protein interactionsautomated screening3D tissue culture
Research Aims
5AIM 01Develop new synthetic methods for DNA-encoded libraries.
AIM 02Create automated systems for drug discovery.
AIM 03Investigate protein-protein interactions for targeted therapies.
AIM 04Utilize 3D tissue culture to enhance drug screening environments.
AIM 05Broaden participation in drug discovery processes.
Skills the Lab Values
DNA sequencingmicrofluidicshigh-throughput screeningchemical synthesisbead-based assaysaffinity selectioncell culture techniquesautomated synthesisbiochemical assays
Output against the department
Publications72bottom 15% of dept.391st of 462
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.346th of 462
this lab
most citedleast cited
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