University of North Carolina at Chapel Hill · Biomedical EngineeringO Diekman Lab
Brian O Diekman · Chapel Hill, North Carolina
Research Focus
Dr. Brian O Diekman's lab studies the effects of DNA damage and cellular aging on osteoarthritis, a common joint disease. They focus on understanding how these factors lead to cell senescence, inflammation, and joint degeneration to develop better treatments. The lab uses advanced techniques to assess the extent of DNA damage and its effects on joint cells, aiming to spark new strategies to prevent and treat osteoarthritis.
DNA damagecellular senescenceosteoarthritisinflammationSASP
Research Aims
3AIM 01Investigate the role of single-strand and double-strand DNA breaks in cellular senescence of joint cells.
AIM 02Analyze how DNA damage influences senescence and osteoarthritis progression in mouse models.
AIM 03Identify protein signatures associated with the senescence-associated secretory phenotype using advanced imaging techniques.
Skills the Lab Values
cell culturemouse modelsintra-articular injectionsflow cytometrymultiplex antibody stainingcomet assayWestern blotimmunofluorescence microscopy
Output against the department
Publications80bottom 12% of dept.522nd of 595
this lab
most publishedleast published
Citations5.6kbottom 43% of dept.340th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.