Harvard University · BiologyCorey Auditory Lab
David P Corey · Cambridge, Massachusetts
Research Focus
Dr. David P. Corey’s lab at Harvard Medical School focuses on understanding and developing therapies for hearing and balance disorders. The lab works on innovative gene therapy techniques to treat hereditary deafness, specifically targeting genetic mutations that cause hearing loss. In addition, they study the fundamental processes of auditory transduction — how sound is converted into electrical signals in the ear, with the ultimate goal of improving treatments for patients with hearing impairments.
gene therapyhereditary deafnessauditory transductiongene editingCRISPR
Research Aims
5AIM 01Develop gene editing strategies to correct mutations in the GJB2 gene.
AIM 02Establish efficient delivery methods for gene editing therapies in auditory cells.
AIM 03Investigate the mechanotransduction processes in auditory hair cells.
AIM 04Characterize the protein interactions between PCDH15 and TMC1.
AIM 05Utilize computational methods to model ion channel gating dynamics.
Skills the Lab Values
gene editingbase editingviral vector packagingmolecular dynamics simulationstransfection of iPSCssingle-cell electrophysiologycryogenic electron microscopyprotein mutagenesisin vivo mouse modelsphysiological recording
Output against the department
Publications216top 29% of dept.302nd of 1,033
this lab
most publishedleast published
Citations26ktop 14% of dept.148th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.