Duke University · GeneticsPetes Genomics Lab
Thomas Petes · Durham, North Carolina
Research Focus
Thomas Petes' research lab at Duke University focuses on understanding the genetic factors that contribute to genome stability, particularly in relation to cancer. Using the yeast model *Saccharomyces cerevisiae*, the lab investigates how mutations and genetic changes lead to genomic instability, which is a hallmark of tumor cells. Research aims include studying mutations related to DNA replication stress, exploring centromere recombination events, and mapping mutations induced by specific proteins to understand their roles in cancer development.
genome stabilityyeast modelgenetic mutationscancer biologygenomic instability
Research Aims
5AIM 01Investigate the mechanisms generating genetic instability in relation to cancer.
AIM 02Characterize mutator effects related to base composition in genome stability.
AIM 03Examine recombination events between centromeres of yeast chromosomes.
AIM 04Map alterations caused by APOBEC-induced mutations in yeast DNA.
AIM 05Study the implications of telomere and centromere mutations on chromosome behavior.
Skills the Lab Values
PCRDNA sequencingyeast geneticsmolecular cloninggenetic recombinationmutation analysisflow cytometryprotein analysiscell culturebioinformatics
Output against the department
Publications205top 41% of dept.106th of 259
this lab
most publishedleast published
Citations16ktop 36% of dept.93rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.