University of Pennsylvania · PharmacologyYim Lab
Yeong Shin Yim · Philadelphia, Pennsylvania
Research Focus
Dr. Yeong Shin Yim's lab at the University of Pennsylvania focuses on how maternal immune responses during pregnancy affect brain development, specifically looking at differences between males and females. Their research investigates a specific signaling pathway (CXCR7/CXCL12) that is linked to neurodevelopmental disorders like autism and schizophrenia. By understanding these differences, the lab aims to uncover new ways to address and potentially prevent issues related to brain development that are influenced by maternal health.
CorticogenesisNeurodevelopmental DisordersCXCR7Maternal Immune ActivationSex DifferencesNeural Progenitor CellsBehavioral ChangesCortical DevelopmentEpigenetic ProfilingPublic Health
Research Aims
5AIM 01Investigate the role of the CXCR7/CXCL12 axis in male and female neural progenitor cell differentiation and migration.
AIM 02Examine the impact of maternal immune activation on cortical development in male offspring.
AIM 03Explore sex-specific patterns of neurodevelopmental vulnerability following maternal immune challenges.
AIM 04Determine how maternal IL-17 signaling affects cortical organization in males and females.
AIM 05Provide insights into potential interventions for neurodevelopmental disorders linked to maternal health.
Skills the Lab Values
Molecular TechniquesCell CultureKnockout Mouse ModelsEpigenetic AnalysisBehavioral AssessmentFlow CytometryImmunohistochemistryRNA SequencingData Analysis with PythonExperimental Design
Output against the department
Publications27bottom 2% of dept.452nd of 462
this lab
most publishedleast published
Citations3.9kbottom 30% of dept.323rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.