Duke University · BiologyCenter for Bladder Immunotherapy
Soman N Abraham · Durham, North Carolina
Research Focus
Dr. Soman N Abraham's lab at Duke University focuses on developing innovative immunotherapies for bladder infections. They aim to improve the effectiveness of existing bladder cancer therapies, specifically the Bacillus Calmette-Guerin (BCG) vaccine, to combat recurrent urinary tract infections caused by bacteria. By combining BCG with specific peptides and antigens, they hope to enhance the immune response and provide long-lasting protection against bladder infections.
BCG vaccineurinary tract infectionimmunotherapyrecurrent infectionsTh1 cells
Research Aims
3AIM 01Determine cellular targets for BCG uptake in the bladder.
AIM 02Identify the immunological basis of protection from bladder infections.
AIM 03Evaluate the efficacy of a combined treatment with BCG, a peptide, and UPEC antigens.
Skills the Lab Values
cell cultureintravesical administrationimmunological assaysantigen identificationanimal models
Output against the department
Publications290top 20% of dept.204th of 1,033
this lab
most publishedleast published
Citations18ktop 22% of dept.225th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.