Cornell University · BiologyImmunoVax Lab
Sarah Caddy · Ithaca, New York
Research Focus
Dr. Sarah Caddy's lab at Cornell University focuses on understanding how maternal antibodies affect the efficacy of oral vaccines in infants. This research is particularly important for improving rotavirus vaccination strategies, especially in low-income countries where rotavirus causes severe gastroenteritis in children. Through studying both human samples and developing mouse models, the lab aims to uncover the mechanisms behind maternal antibody interference and identify ways to enhance vaccine responses in infants.
maternal antibodiesrotavirusvaccine efficacyneonatal immunityoral vaccination
Research Aims
5AIM 01Investigate the mechanisms of maternal antibody interference with rotavirus vaccines.
AIM 02Analyze human clinical samples for maternal antibody characteristics.
AIM 03Develop mouse models to study the impact of maternal antibodies on vaccine response.
AIM 04Determine the role of placental and breast milk antibodies in vaccine interference.
AIM 05Identify potential new vaccine strategies to overcome maternal antibody interference.
Skills the Lab Values
mouse modelsmonoclonal antibody technologyantibody assaysbiophysical analysistransgenic mice
Output against the department
Publications107bottom 37% of dept.649th of 1,033
this lab
most publishedleast published
Citations5.0kbottom 38% of dept.641st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.