Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologySimon Lab
Viviana A Simon · New York, New York
Research Focus
Dr. Viviana A Simon's research lab focuses on understanding HIV and coronavirus infections, particularly why some people can carry these viruses for long periods without clearing them. The lab employs advanced techniques to investigate how different immune cells interact with viruses like HIV and SARS-CoV-2. Additionally, they are working on developing vaccines that can provide broad protection against various coronaviruses. This lab combines clinical studies with cutting-edge molecular biology to uncover key insights that could lead to effective treatments and vaccines.
HIV latencySARS-CoV-2coronavirus immunologyviral evolutionvaccinesB cell responseT lymphocyteslatent infectionsantibody developmentimmune response
Research Aims
5AIM 01Investigate the structural differences between productive and non-productive HIV infections in CD4+ T cells.
AIM 02Analyze the clinical features associated with persistent SARS-CoV-2 infections.
AIM 03Identify the immunological factors that drive long-lasting antibody responses to coronaviruses.
AIM 04Develop and test vaccines that can provide protection against SARS-CoV-2 variants.
AIM 05Elucidate the mechanisms of viral evolution during chronic infections.
Skills the Lab Values
PCRRNA sequencingcell culturegenome editingbioinformaticslong-read transcriptome analysisflow cytometrymouse modelsviral genotypingmonoclonal antibody development