University of Southern California · PhysiologyThe Alzheimer’s Discovery Lab
Robert Rissman · Los Angeles, California
Research Focus
Dr. Robert Rissman's lab focuses on Alzheimer's disease, particularly in individuals with Down syndrome and diverse ethnic backgrounds. The research aims to develop personalized treatment strategies by using plasma biomarkers to understand the disease's progression and different responses to therapies. By analyzing these biomarkers, the lab hopes to improve early detection and treatment outcomes for Alzheimer's disease, especially within underrepresented populations.
Alzheimer's diseaseDown syndromebiomarkersethnicityprecision medicineanti-inflammatory treatmentproteomicsclinical trialshealth disparities
Research Aims
5AIM 01Investigate the biological differences in Alzheimer's disease among individuals with Down syndrome.
AIM 02Develop better therapeutic trials for Alzheimer's disease using identified biomarkers.
AIM 03Characterize plasma biomarkers of Alzheimer's disease in diverse populations.
AIM 04Assess how ethnicity and race affect Alzheimer's disease biomarkers and outcomes.
AIM 05Advance precision medicine approaches for treating Alzheimer's disease.
Skills the Lab Values
high throughput proteomicsbiobankingplasma analysisclinical trial methodologybiofluid assaysdata modelingcognitive testingethnic health disparity researchpredictive modeling
Output against the department
Publications425top 9% of dept.25th of 286
this lab
most publishedleast published
Citations21ktop 12% of dept.33rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.