University of Rochester · PharmacologyMuscle Disease Mechanisms Lab
Robert T Dirksen · Rochester, New York
Research Focus
Dr. Robert Dirksen's lab focuses on understanding tubular aggregate myopathy (TAM), a genetic muscle disease that affects strength and endurance. The team utilizes specially designed mouse models to explore the underlying mechanisms of this disease and to test potential treatments. Their work aims to provide new insights that could ultimately lead to effective therapies for people suffering from TAM.
tubular aggregate myopathymuscle diseaseCa2+ entryexercise therapymouse modelsmyopathy mechanismstherapeutic interventionsgenetic mutationsmuscle strength
Research Aims
3AIM 01Identify pathogenic mechanisms underlying tubular aggregate myopathy.
AIM 02Examine differences in muscle function between Orai1 and Casq1 mutation mouse models.
AIM 03Test the effects of exercise mimetic therapy on myopathy progression.
Skills the Lab Values
mouse modelsmuscle histologygene editingCa2+ imagingexercise mimicry techniquesprotein assaysmolecular biology techniquesdata collection and analysisbiochemical assays
Output against the department
Publications283top 27% of dept.127th of 462
this lab
most publishedleast published
Citations12ktop 31% of dept.143rd of 462
this lab
most citedleast cited
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